|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
One hypothesis is that a SNP (Thr92Ala) in DIO2 (required for local production of T3 out of T4) interferes with its kinetics and/or action, resulting in a local hypothyroid state in the brain.
|
31617166 |
2019 |
|
Thyroxine measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.
|
30367059 |
2018 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
A new report indicates that carriers of the Thr92Ala-DIO2 polymorphism exhibit lower D2 catalytic activity and localized/systemic hypothyroidism.
|
30063552 |
2018 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Seven SNPs in the DIO2 gene - rs225014 (Thr92Ala), rs12885300, rs2267872, rs225011, rs224995, rs225015, and rs2267873 - were studied to assess their association with GD and GO.
|
30574458 |
2018 |
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, African American carriers of Thr92Ala-DIO2 exhibit an about 30% higher risk of developing Alzheimer's disease.
|
30063552 |
2018 |
|
Hypertensive disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
There are a number of reports describing the association between the Thr92Ala-DIO2 polymorphism and clinical syndromes that include hypertension, type 2 diabetes, mental disorders, lung injury, bone turnover, and autoimmune thyroid disease; but these associations have not been reproduced in all population studies.
|
30063552 |
2018 |
|
Thyroid associated opthalmopathies
|
|
0.010 |
GeneticVariation
|
BEFREE |
Seven SNPs in the DIO2 gene - rs225014 (Thr92Ala), rs12885300, rs2267872, rs225011, rs224995, rs225015, and rs2267873 - were studied to assess their association with GD and GO.
|
30574458 |
2018 |
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the D2 rs225014 polymorphism, the TT genotype, which was correlated with higher D2 activity, was less frequent in AITD, especially in HD, than in control subjects (P = 0.0032 and 0.0002, respectively).
|
29648895 |
2018 |
|
Thyroid Hormone Metabolism, Abnormal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two patients with clinical evidence of abnormal thyroid hormone metabolism were identified and found to have TSHR mutations as well as DIO2 T92A single nucleotide polymorphism (SNP).
|
29973617 |
2018 |
|
Degenerative disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Indeed, brain samples of Thr92Ala-DIO2 carriers exhibit gene profiles suggestive of brain degenerative disease.
|
30063552 |
2018 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
Thyroidectomized patients carrying Thr92Ala are at increased risk of reduced intracellular and serum T3 concentrations that are not adequately compensated for by LT4, thus providing evidence in favor of customized treatment of hypothyroidism in athyreotic patients.
|
28324063 |
2017 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
The present study indicates that the combination of polymorphisms in <i>DIO2</i> (rs225014) and <i>MCT10</i> (rs17606253) enhances hypothyroid patients' preference for L-T4 + L-T3 replacement therapy.
|
28785541 |
2017 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
In both groups, the D2-Thr92Ala polymorphism was not associated with differences in TSH, fT4, fT3, the fT3/fT4 ratio, presence of metabolic syndrome or other comorbidities, use of medication, HRQoL, and cognitive functioning.
|
27786042 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients.
|
27777960 |
2016 |
|
Kashin-Beck Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The meta-analysis of the GPX1 rs1050450, DIO2 rs225014, TrxR2 rs5748469 and HLA-DRB1 rs7745040 failed to reveal any associations with KBD.
|
27256326 |
2016 |
|
Recurrent depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The specific variant of the DIO2 gene, namely the CC genotype of the Thr92Ala polymorphism, was more frequently found in healthy subjects than in patients with depression, what suggests that it could potentially serve as a marker of a lower risk for recurrent depressive disorder.
|
26098717 |
2015 |
|
Recurrent depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current study investigates whether a specific single nucleotide polymorphism (SNP) of the DIO2 gene, Thr92Ala (T/C); rs 225014 or ORFa-Gly3Asp (C/T); rs 12885300, correlate with the risk for recurrent depression.
|
26098717 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, the rs225017 polymorphism is associated with greater IR in T2DM and it seems to interact with the Thr92Ala polymorphism in the modulation of IR.
|
25105294 |
2014 |
|
Hypothyroidism
|
|
0.050 |
GeneticVariation
|
BEFREE |
A polymorphism (Thr92Ala) in the gene encoding the deiodinase 2 (D2) enzyme that converts thyroxine to triiodothyronine in the brain was later identified in about 16% of hypothyroid persons.
|
22548953 |
2013 |
|
Kashin-Beck Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we showed that single SNPs in the genes GPX1 (rs1050450, rs1800668 and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) may not be significantly associated with KBD in a Tibetan population.
|
24058403 |
2013 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Prevalence of Dio2(T92A) polymorphism and its association with thyroid autoimmunity.
|
23013882 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.060 |
GeneticVariation
|
BEFREE |
The Thr92Ala variant common in Pima Indians, rs225011, and rs225015 were modestly associated with early-onset T2DM (p=0.01-0.04) in the case-control study, but were not associated with obesity in the obesity case-control study, nor associated with T2DM (at any age) or body-mass index (BMI; as a quantitative trait) in the family-based analysis.
|
22142372 |
2012 |
|
Obesity
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Thr92Ala variant common in Pima Indians, rs225011, and rs225015 were modestly associated with early-onset T2DM (p=0.01-0.04) in the case-control study, but were not associated with obesity in the obesity case-control study, nor associated with T2DM (at any age) or body-mass index (BMI; as a quantitative trait) in the family-based analysis.
|
22142372 |
2012 |
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The allelic imbalance of the DIO2 mRNA transcript, with the OA risk allele 'C' of rs225014 more abundant than the wild-type 'T' allele in heterozygote carriers provides a possible mechanism by which genetic variation at DIO2 confers OA risk.
|
22492780 |
2012 |
|
Metabolic Syndrome X
|
|
0.030 |
GeneticVariation
|
BEFREE |
Recently, it was reported that the D2 Thr92Ala (rs225014) and the peroxisome proliferator-activated receptor (PPAR) γ2 Pro12Ala (rs1801282) polymorphisms interact in the modulation of metabolic syndrome in nondiabetic subjects.
|
20930717 |
2011 |